InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LY96

Summary

InnateDB Gene

IDBG-25842.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LY96

Gene Name

lymphocyte antigen 96

Synonyms

ESOP-1; ly-96; MD-2; MD2

Species

Homo sapiens

Ensembl Gene

ENSG00000154589

Encoded Proteins

IDBP-25844

lymphocyte antigen 96

IDBP-484629

lymphocyte antigen 96

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19840871

LY96 (MD-2) recognizes only exogenous pathogen-associated molecular patterns (PAMPs) when complexed with TLR2-CD14 or TLR4-CD14.

PMID 15852007

LY86 and CD180 interact directly with the TLR4 signalling complex, inhibiting its ability to bind microbial ligand.

PMID 10359581

LY96 is physically associated with TLR4 on the cell surface and confers responsiveness to lipopolysaccharide (LPS).

PMID 21712422

TLR4::LY96 functions as intracellular LPS sensor and triggers a unique set of LPS responses upon recognition of phagocytosed bacteria in macrophages. (Demonstrated in murine model)

PMID 22433852

Amino acid Phe126 of LY96 acts as a hydrophobic switch driving agonist-dependent contacts necessary for TLR4 dimerization and activation.

PMID 22474354

Morphine binds to LY96, triggering TLR4 oligomerization and induces neuroinflammation within the central nervous system.

InnateDB Annotation from Orthologs

Summary

PMID 21712422

[Mus musculus] Tlr4::Ly96 functions as intracellular LPS sensor and triggers a unique set of LPS responses upon recognition of phagocytosed bacteria in macrophages.

PMID 22433852

[Mus musculus] Amino acid Phe126 of Ly96 acts as a hydrophobic switch driving agonist-dependent contacts necessary for Tlr4 dimerization and activation. (Demonstrated in human)

PMID 22474354

[Mus musculus] Morphine binds to Ly96, triggering Tlr4 oligomerization and induces neuroinflammation within the central nervous system. (Demonstrated in human)

Entrez Gene

Summary

This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:73991352-74029087

Strand

Forward strand

Band

q21.11

Transcripts

ENST00000284818	ENSP00000284818
ENST00000518893	ENSP00000430533

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	19 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001875	lipopolysaccharide receptor activity
GO:0005515	protein binding
GO:0015026	coreceptor activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0002756	MyD88-independent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0006968	cellular defense response
GO:0007166	cell surface receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0031663	lipopolysaccharide-mediated signaling pathway
GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032497	detection of lipopolysaccharide
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034138	toll-like receptor 3 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0035666	TRIF-dependent toll-like receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0045087	innate immune response (InnateDB)