InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2ak4

Summary

InnateDB Protein

IDBP-259320.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Eif2ak4

Protein Name

eukaryotic translation initiation factor 2 alpha kinase 4

Synonyms

2610011M03; GCN2; MGCN2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106496

InnateDB Gene

IDBG-198013 (Eif2ak4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0009267	cellular response to starvation
GO:0017148	negative regulation of translation
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0043558	regulation of translational initiation in response to stress

Cellular Component

Protein Structure and Domains

PDB ID

MGI:1353427

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR004154 Anticodon-binding
IPR011009 Protein kinase-like domain
IPR016135 Ubiquitin-conjugating enzyme/RWD-like
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF03129

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt