Version 5.4
Mus musculus Gene: Eif2ak4
Summary
InnateDB Gene IDBG-198013.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif2ak4
Gene Name eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms 2610011M03; GCN2; MGCN2
Species Mus musculus
Ensembl Gene ENSMUSG00000005102
Encoded Proteins
IDBP-198015
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-198017
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-259314
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-259318
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-259320
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-259322
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-259324
eukaryotic translation initiation factor 2 alpha kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000128829:
EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:118388618-118475234
Strand Forward strand
Band E5
Transcripts
ENSMUST00000005233 ENSMUSP00000005233
ENSMUST00000102527 ENSMUSP00000099586
ENSMUST00000110877 ENSMUSP00000106501
ENSMUST00000110874 ENSMUSP00000106498
ENSMUST00000110872 ENSMUSP00000106496
ENSMUST00000110870 ENSMUSP00000106494
ENSMUST00000110869 ENSMUSP00000106493
ENSMUST00000125281
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0006446 regulation of translational initiation
GO:0006468 protein phosphorylation
GO:0009267 cellular response to starvation
GO:0017148 negative regulation of translation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0043558 regulation of translational initiation in response to stress
Cellular Component
GO:0022626 cytosolic ribosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000128829
View Gene Order
ENSBTAG00000014351
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04141
Protein processing in endoplasmic reticulum pathway
mmu05160
Hepatitis C pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt Q9QZ05
TrEMBL A2AUM2
UniProt Splice Variant
Entrez Gene 27103
UniGene Mm.217616
RefSeq NM_001177806 XM_006499625 NM_013719 XM_006499626 XM_006499627 XM_006499628
OMIM
CCDS CCDS50669 CCDS16576
HPRD
IMGT
MGI ID MGI:1353427
MGI Symbol Eif2ak4
EMBL AF193342 AF193343 AF193344 AJ243533 AK011380 AK013758 AK077199 AK129334 AL929163 BC023958 BC072637
GenPept AAG22589 AAG22590 AAG22591 AAH23958 AAH72637 BAB27580 BAB28984 BAC36677 BAC98144 CAB58363 CAM24689 CAM24690
RNA Seq Atlas 27103

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca