InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif2ak4

Summary

InnateDB Protein

IDBP-259322.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif2ak4

Protein Name

eukaryotic translation initiation factor 2 alpha kinase 4

Synonyms

2610011M03; GCN2; MGCN2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106494

InnateDB Gene

IDBG-198013 (Eif2ak4)

Protein Structure

UniProt Annotation

Function

Can phosphorylate the alpha subunit of EIF2 and may mediate translational control.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in liver (at protein level). Widely expressed, with the highest levels in the liver and the brain. Isoform 4 is expressed in brain followed by testis and liver and isoform 3 is expressed only in brain. {ECO:0000269PubMed:10504407}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004694	eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042803	protein homodimerization activity

Biological Process

GO:0006446	regulation of translational initiation
GO:0006468	protein phosphorylation
GO:0009267	cellular response to starvation
GO:0017148	negative regulation of translation
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0043558	regulation of translational initiation in response to stress

Cellular Component

GO:0022626

cytosolic ribosome

Protein Structure and Domains

PDB ID

MGI:1353427

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR004154 Anticodon-binding
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF03129

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt