InnateDB Protein
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IDBP-2598.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DERL3
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Protein Name
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Der1-like domain family, member 3
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000315303
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InnateDB Gene
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IDBG-2596 (DERL3)
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Protein Structure
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Function |
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. {ECO:0000269PubMed:16449189, ECO:0000269PubMed:22607976}.
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Subcellular Localization |
Endoplasmic reticulum membrane {ECO:0000269PubMed:16449189}; Multi-pass membrane protein {ECO:0000269PubMed:16449189}.
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Disease Associations |
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Tissue Specificity |
Unlike DERL1 and DERL2, restricted to several tissues. Expressed at high levels in placenta, pancreas, spleen and small intestine. {ECO:0000269PubMed:16449189}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
GO:0018279
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protein N-linked glycosylation via asparagine
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GO:0030433
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ER-associated ubiquitin-dependent protein catabolic process
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GO:0030968
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endoplasmic reticulum unfolded protein response
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Cellular Component |
GO:0030176
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integral component of endoplasmic reticulum membrane
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PDB ID |
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InterPro |
IPR007599
Derlin
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PFAM |
PF04511
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96Q80
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
91319
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UniGene |
Hs.593679
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RefSeq |
NP_001002862
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HUGO |
HGNC:14236
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OMIM |
610305
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CCDS |
CCDS33615
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HPRD |
13139
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IMGT |
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EMBL |
AB049213
AK125830
AL389876
AP000350
BC057830
CR456372
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GenPept |
AAH57830
BAB68409
BAC86311
CAG30258
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