Homo sapiens Gene: DERL3
Summary
InnateDB Gene IDBG-2596.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DERL3
Gene Name derlin 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099958
Encoded Proteins
Der1-like domain family, member 3
Der1-like domain family, member 3
Der1-like domain family, member 3
Der1-like domain family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:23834503-23839128
Strand Reverse strand
Band q11.23
Transcripts
ENST00000318109 ENSP00000315303
ENST00000290730
ENST00000406855 ENSP00000384744
ENST00000404056 ENSP00000384473
ENST00000464023
ENST00000493596
ENST00000464034
ENST00000488272
ENST00000476077 ENSP00000419399
ENST00000464110
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
Cellular Component
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Protein processing in endoplasmic reticulum pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.593679
RefSeq NM_001002862 NM_001135751 NM_198440
HUGO
OMIM
CCDS CCDS33615 CCDS42986 CCDS46672
HPRD 13139
IMGT
EMBL
GenPept
RNA Seq Atlas