Version 5.4
Homo sapiens Gene: DERL3
Summary
InnateDB Gene IDBG-2596.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DERL3
Gene Name derlin 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099958
Encoded Proteins
IDBP-2598
Der1-like domain family, member 3
IDBP-292795
Der1-like domain family, member 3
IDBP-292802
Der1-like domain family, member 3
IDBP-482898
Der1-like domain family, member 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the derlin family, and resides in the endoplasmic reticulum (ER). Proteins that are unfolded or misfolded in the ER must be refolded or degraded to maintain the homeostasis of the ER. This protein appears to be involved in the degradation of misfolded glycoproteins in the ER. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:23834503-23839128
Strand Reverse strand
Band q11.23
Transcripts
ENST00000318109 ENSP00000315303
ENST00000290730
ENST00000406855 ENSP00000384744
ENST00000404056 ENSP00000384473
ENST00000464023
ENST00000493596
ENST00000464034
ENST00000488272
ENST00000476077 ENSP00000419399
ENST00000464110
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0030968 endoplasmic reticulum unfolded protein response
Cellular Component
GO:0030176 integral component of endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009092
View Gene Order
ENSBTAG00000022028
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt Q96Q80
TrEMBL E7EVA4
UniProt Splice Variant
Entrez Gene 91319
UniGene Hs.593679
RefSeq NM_001002862 NM_001135751 NM_198440
HUGO HGNC:14236
OMIM 610305
CCDS CCDS33615 CCDS42986 CCDS46672
HPRD
IMGT
EMBL AB049213 AK125830 AL389876 AP000350 BC057830 CR456372
GenPept AAH57830 BAB68409 BAC86311 CAG30258
RNA Seq Atlas 91319

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca