InnateDB Protein
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IDBP-260063.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Agxt2
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Protein Name
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alanine-glyoxylate aminotransferase 2
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000106171
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InnateDB Gene
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IDBG-486570 (Agxt2)
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Protein Structure
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Function |
Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. {ECO:0000269PubMed:23023372}.
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Subcellular Localization |
Mitochondrion {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2146052
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InterPro |
IPR005814
Aminotransferase class-III
IPR015424
Pyridoxal phosphate-dependent transferase
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PFAM |
PF00202
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PRINTS |
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PIRSF |
PIRSF000521
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3UEG6
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PhosphoSite |
PhosphoSite-Q3UEG6
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
268782
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UniGene |
Mm.482244
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RefSeq |
XP_006520130
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MGI ID |
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MGI Symbol |
Agxt2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK149538
BC141248
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GenPept |
AAI41249
BAE28945
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