Version 5.4
Mus musculus Gene: Agxt2
Summary
InnateDB Gene IDBG-486570.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agxt2
Gene Name alanine-glyoxylate aminotransferase 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000089678
Encoded Proteins
IDBP-129320
alanine-glyoxylate aminotransferase 2
IDBP-260063
alanine-glyoxylate aminotransferase 2
IDBP-260065
alanine-glyoxylate aminotransferase 2
IDBP-260067
alanine-glyoxylate aminotransferase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113492:
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor. [provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:10358532-10410153
Strand Forward strand
Band A1
Transcripts
ENSMUST00000022858 ENSMUSP00000022858
ENSMUST00000110542 ENSMUSP00000106171
ENSMUST00000110541 ENSMUSP00000106170
ENSMUST00000110540 ENSMUSP00000106169
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008453 alanine-glyoxylate transaminase activity
GO:0008483 transaminase activity
GO:0016223 beta-alanine-pyruvate transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047305 (R)-3-amino-2-methylpropionate-pyruvate transaminase activity
Biological Process
GO:0008152 metabolic process
GO:0009436 glyoxylate catabolic process
GO:0019265 glycine biosynthetic process, by transamination of glyoxylate
GO:0019481 L-alanine catabolic process, by transamination
GO:0045429 positive regulation of nitric oxide biosynthetic process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113492
View Gene Order
ENSBTAG00000007690
Not yet available
Pathways
NETPATH
REACTOME
REACT_236186
Pyrimidine metabolism pathway
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_261828
Glyoxylate metabolism pathway
REACT_241108
Pyrimidine catabolism pathway
REACT_245662
Metabolism of nucleotides pathway
KEGG
mmu00260
Glycine, serine and threonine metabolism pathway
mmu00250
Alanine, aspartate and glutamate metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16925
Glyoxylate metabolism pathway
REACT_1023
Pyrimidine catabolism pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_957
Pyrimidine metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00260
Glycine, serine and threonine metabolism pathway
hsa00250
Alanine, aspartate and glutamate metabolism pathway
INOH
INOH website
Glycolysis Gluconeogenesis pathway
INOH website
Alanine Aspartate Asparagine metabolism pathway
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL D3YZ52
UniProt Splice Variant
Entrez Gene 268782
UniGene Mm.442680 Mm.482244
RefSeq NM_001031851 XM_006520067 XM_006520068
OMIM
CCDS CCDS27378
HPRD
IMGT
MGI ID MGI:2146052
MGI Symbol Agxt2
EMBL AC102101
GenPept
RNA Seq Atlas 268782

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca