InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Flt1

Summary

InnateDB Protein

IDBP-260069.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Flt1

Protein Name

FMS-like tyrosine kinase 1

Synonyms

AI323757; Flt-1; sFlt1; VEGFR-1; VEGFR1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000106158

InnateDB Gene

IDBG-209098 (Flt1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005021	vascular endothelial growth factor-activated receptor activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0042802	identical protein binding

Biological Process

GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0002040	sprouting angiogenesis
GO:0006468	protein phosphorylation
GO:0016477	cell migration
GO:0038084	vascular endothelial growth factor signaling pathway
GO:0048010	vascular endothelial growth factor receptor signaling pathway

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

MGI:95558

InterPro

IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR009135 Vascular endothelial growth factor receptor 1 (VEGFR1)
IPR013098 Immunoglobulin I-set
IPR013106 Immunoglobulin V-set domain
IPR013151 Immunoglobulin

PFAM

PF07679
PF07686
PF00047

PRINTS

PR01833

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q9CSC8

UniProt Splice Variant

Entrez Gene

14254

UniGene

Mm.401078

RefSeq

MGI ID

MGI Symbol

Flt1

OMIM

CCDS

HPRD

IMGT

EMBL

AC122299 AC131730 AJ001177 AK013236 AK146906 D88690

GenPept

BAA24499 BAB28733 BAE27519 CAA04571