InnateDB Protein
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IDBP-26053.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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FBXL12
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Protein Name
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F-box and leucine-rich repeat protein 12
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000247977
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InnateDB Gene
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IDBG-26051 (FBXL12)
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Protein Structure
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Function |
Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia. {ECO:0000269PubMed:23707388}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
22
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001810
F-box domain
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PFAM |
PF00646
PF12937
PF13013
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PRINTS |
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PIRSF |
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SMART |
SM00256
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TIGRFAMs |
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Modification |
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SwissProt |
Q9NXK8
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PhosphoSite |
PhosphoSite-Q9NXK8
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TrEMBL |
K7EPN7
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UniProt Splice Variant |
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Entrez Gene |
54850
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UniGene |
Hs.12439
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RefSeq |
NP_060173
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HUGO |
HGNC:13611
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OMIM |
609079
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CCDS |
CCDS12218
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HPRD |
12363
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IMGT |
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EMBL |
AC008752
AK000195
AK027004
AK093760
BC001586
CH471106
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GenPept |
AAH01586
BAA91002
BAB15622
BAG52760
EAW84051
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