Homo sapiens Gene: FBXL12
Summary
InnateDB Gene IDBG-26051.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXL12
Gene Name F-box and leucine-rich repeat protein 12
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127452
Encoded Proteins
F-box and leucine-rich repeat protein 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the F-box protein family, such as FBXL12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:9810267-9827816
Strand Reverse strand
Band p13.2
Transcripts
ENST00000247977 ENSP00000247977
ENST00000592067 ENSP00000464784
ENST00000590808 ENSP00000466142
ENST00000590277 ENSP00000467467
ENST00000586651 ENSP00000467059
ENST00000588922 ENSP00000468033
ENST00000591009 ENSP00000468369
ENST00000586469 ENSP00000467859
ENST00000592732 ENSP00000468766
ENST00000589438 ENSP00000467523
ENST00000586073 ENSP00000465439
ENST00000585379 ENSP00000467359
ENST00000589626 ENSP00000464858
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 22 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016567 protein ubiquitination
Cellular Component
GO:0000151 ubiquitin ligase complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q9NXK8
TrEMBL K7EIK3 K7EIR3 K7EK37 K7ELM5 K7EPN7 K7EPT3 K7EQJ7 K7EQY7
UniProt Splice Variant
Entrez Gene 54850
UniGene Hs.12439
RefSeq NM_017703 XM_005259964 XM_005259966 XM_006722782
HUGO HGNC:13611
OMIM 609079
CCDS CCDS12218
HPRD
IMGT
EMBL AC008752 AK000195 AK027004 AK093760 BC001586 CH471106
GenPept AAH01586 BAA91002 BAB15622 BAG52760 EAW84051
RNA Seq Atlas 54850