InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tgm3

Summary

InnateDB Protein

IDBP-260567.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tgm3

Protein Name

transglutaminase 3, E polypeptide

Synonyms

AI893889; TG E; TG(E); TGase E; TGase-3; TGE;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105928

InnateDB Gene

IDBG-206095 (Tgm3)

Protein Structure

UniProt Annotation

Function

Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross- linking structural proteins to hardening the inner root sheath. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed in skin and stomach and, at lower levels, in testis, kidney and spleen (at protein level). On the basis of its catalytic activity, detected in the epidermis, around the granular and spinous layers but not in the outermost cornified layers. In hair follicles, mainly located in the medulla and the hair cortex. {ECO:0000269PubMed:11331204, ECO:0000269PubMed:20716179}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003810	protein-glutamine gamma-glutamyltransferase activity
GO:0003824	catalytic activity
GO:0003924	GTPase activity
GO:0005509	calcium ion binding
GO:0005525	GTP binding
GO:0019003	GDP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0008544	epidermis development
GO:0018149	peptide cross-linking
GO:0030216	keratinocyte differentiation
GO:0031424	keratinization
GO:0035315	hair cell differentiation
GO:0043163	cell envelope organization
GO:0043588	skin development
GO:0051262	protein tetramerization

Cellular Component

GO:0001533	cornified envelope
GO:0005737	cytoplasm
GO:0031234	extrinsic component of cytoplasmic side of plasma membrane
GO:0070062	extracellular vesicular exosome