InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ebf4

Summary

InnateDB Protein

IDBP-260591.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ebf4

Protein Name

early B-cell factor 4

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105915

InnateDB Gene

IDBG-206321 (Ebf4)

Protein Structure

UniProt Annotation

Function

Seems to weakly activate transcription. Binds an Olf-1 consensus site in vitro.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed in the neuronal and basal cell layers of olfactory epithelium. Absent in the vomeronasal organ. {ECO:0000269PubMed:12139918}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001228	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0046872	metal ion binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007275	multicellular organismal development
GO:0045944	positive regulation of transcription from RNA polymerase II promoter