InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIN1

Summary

InnateDB Protein

IDBP-26089.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIN1

Protein Name

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Synonyms

DOD; UBL5;

Species

Homo sapiens

Ensembl Protein

ENSP00000247970

InnateDB Gene

IDBG-26087 (PIN1)

Protein Structure

UniProt Annotation

Function

Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans isomerizations. Down-regulates kinase activity of BTK. Can transactivate multiple oncogenes and induce centrosome amplification, chromosome instability and cell transformation. Required for the efficient dephosphorylation and recycling of RAF1 after mitogen activation. Binds and targets PML and BCL6 for degradation in a phosphorylation-dependent manner. {ECO:0000269PubMed:15664191, ECO:0000269PubMed:16644721, ECO:0000269PubMed:17828269, ECO:0000269PubMed:21497122, ECO:0000269PubMed:22033920}.

Subcellular Localization

Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with NEK6 in the nucleus. Mainly localized in the nucleus but phosphorylation at Ser-71 by DAPK1 results in inhibition of its nuclear localization.

Disease Associations

Tissue Specificity

The phosphorylated form at Ser-71 is expressed in normal breast tissue cells but not in breast cancer cells. {ECO:0000269PubMed:17828269, ECO:0000269PubMed:21497122}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 256 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	256 [view]
Protein-Protein	251 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0032794	GTPase activating protein binding
GO:0050815	phosphoserine binding
GO:0050816	phosphothreonine binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0001934	positive regulation of protein phosphorylation
GO:0006457	protein folding
GO:0007049	cell cycle
GO:0007088	regulation of mitosis
GO:0019221	cytokine-mediated signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032321	positive regulation of Rho GTPase activity
GO:0032465	regulation of cytokinesis
GO:0032480	negative regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:2000146	negative regulation of cell motility