InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PIN1

Summary

InnateDB Gene

IDBG-26087.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIN1

Gene Name

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

Synonyms

DOD; UBL5

Species

Homo sapiens

Ensembl Gene

ENSG00000127445

Encoded Proteins

IDBP-26089

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

IDBP-763469

IDBP-765966

IDBP-761022

IDBP-762662

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 16699525

PIN1 negatively regulates IRF3-dependent innate antiviral response by binding to phosphorylated IRF3 for proteasome-dependent degradation.

PMID 21743479

PIN1 is necessary to mount TLR-mediated, interferon-dependent innate and adaptive immune response. PIN1 is activated by TLR7 and TLR9, which binds to IRAK1 to activate IRF7 which then induce type I interferons. (Demonstrated in mouse)

InnateDB Annotation from Orthologs

Summary

PMID 21743479

[Mus musculus] Pin1 is necessary to mount TLR-mediated, interferon-dependent innate and adaptive immune response. Pin1 is activated by Tlr7 and Tlr9, which binds to Irak1 to activate Irf7 which then induce type I interferons.

Entrez Gene

Summary

Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer\'s disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:9835257-9849682

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000247970	ENSP00000247970
ENST00000380889
ENST00000588695	ENSP00000466962
ENST00000586025
ENST00000591777	ENSP00000466780
ENST00000589058
ENST00000590540
ENST00000592184
ENST00000586352	ENSP00000467197
ENST00000587625	ENSP00000466656
ENST00000585442

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 256 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	256 [view]
Protein-Protein	251 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0032794	GTPase activating protein binding
GO:0050815	phosphoserine binding
GO:0050816	phosphothreonine binding

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0001934	positive regulation of protein phosphorylation
GO:0006457	protein folding
GO:0007049	cell cycle
GO:0007088	regulation of mitosis
GO:0019221	cytokine-mediated signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032321	positive regulation of Rho GTPase activity
GO:0032465	regulation of cytokinesis
GO:0032480	negative regulation of type I interferon production
GO:0045087	innate immune response (InnateDB)
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:2000146	negative regulation of cell motility