InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Asap1

Summary

InnateDB Protein

IDBP-260948.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Asap1

Protein Name

ArfGAP with SH3 domain, ankyrin repeat and PH domain1

Synonyms

AV239055; Ddef1; DEF-1; mKIAA1249; PAP; s19;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105742

InnateDB Gene

IDBG-145005 (Asap1)

Protein Structure

UniProt Annotation

Function

May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis (By similarity). Posseses phosphatidylinositol 4,5-bisphosphate-dependent GTPase- activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. {ECO:0000250}.

Subcellular Localization

Cytoplasm. Membrane. Note=Predominantly cytoplasmic. Partially membrane-associated.

Disease Associations

Tissue Specificity

Expressed in all tissues examined but a most abundant expression was found in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals. {ECO:0000269PubMed:10022919}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	27 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding

Biological Process

GO:0032312	regulation of ARF GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0060271	cilium morphogenesis

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:1342335

InterPro

IPR001164 Arf GTPase activating protein
IPR001452 SH3 domain
IPR001849 Pleckstrin homology domain
IPR002110 Ankyrin repeat
IPR011511 Variant SH3 domain
IPR020683 Ankyrin repeat-containing domain

PFAM