Version 5.4
Mus musculus Gene: Asap1
Summary
InnateDB Gene IDBG-145005.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asap1
Gene Name ArfGAP with SH3 domain, ankyrin repeat and PH domain1
Synonyms AV239055; Ddef1; DEF-1; mKIAA1249; PAP; s19
Species Mus musculus
Ensembl Gene ENSMUSG00000022377
Encoded Proteins
IDBP-145007
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
IDBP-260948
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
IDBP-260950
ArfGAP with SH3 domain, ankyrin repeat and PH domain1
IDBP-744144
IDBP-744211
IDBP-743987
IDBP-744005
IDBP-744030
IDBP-743963
IDBP-744015
IDBP-743704
IDBP-744023
IDBP-743847
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153317:
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:64086857-64382919
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000023008 ENSMUSP00000023008
ENSMUST00000110115 ENSMUSP00000105742
ENSMUST00000110114 ENSMUSP00000105741
ENSMUST00000175793 ENSMUSP00000135718
ENSMUST00000177371 ENSMUSP00000135643
ENSMUST00000177374 ENSMUSP00000134825
ENSMUST00000177475
ENSMUST00000175799 ENSMUSP00000135359
ENSMUST00000176384 ENSMUSP00000135190
ENSMUST00000177035 ENSMUSP00000135346
ENSMUST00000175710
ENSMUST00000176821
ENSMUST00000176516
ENSMUST00000176014 ENSMUSP00000135172
ENSMUST00000176358 ENSMUSP00000135239
ENSMUST00000175963 ENSMUSP00000135047
ENSMUST00000176909
ENSMUST00000176427
ENSMUST00000177083 ENSMUSP00000134877
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
GO:0060271 cilium morphogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153317
View Gene Order
ENSBTAG00000003185
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04144
Endocytosis pathway
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
arf_3pathway
Arf1 pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.277236 Mm.412974 Mm.418585
RefSeq NM_001276461 NM_001276462 NM_001276463 NM_001276467 NM_010026 XM_006520392 XM_006520393 XM_006520396 XM_006520397 XM_006520398 XM_006520399 XM_006520402 XM_006520403
OMIM
CCDS CCDS56986 CCDS70631 CCDS70632 CCDS70633 CCDS70634
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca