InnateDB Protein
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IDBP-261715.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Siva1
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Protein Name
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SIVA1, apoptosis-inducing factor
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Synonyms
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CD27bp; Siva;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000105377
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InnateDB Gene
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IDBG-174589 (Siva1)
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Protein Structure
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Function |
Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa- B and promotes T-cell receptor-mediated apoptosis (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm. Nucleus {ECO:0000250}. Note=In the nucleus, accumulates in dot-like structures. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in testis, heart, liver, lung, and muscle, and less in kidney, spleen and brain.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
18 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1353606
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InterPro |
IPR022773
Siva
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PFAM |
PF05458
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PRINTS |
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PIRSF |
PIRSF038096
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O54926
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
30954
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UniGene |
Mm.407012
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RefSeq |
NP_001155209
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MGI ID |
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MGI Symbol |
Siva1
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OMIM |
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CCDS |
CCDS49189
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HPRD |
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IMGT |
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EMBL |
AF033112
AF033113
AF033114
AF033115
AK010562
AK017570
AK153115
BC012279
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GenPept |
AAC04706
AAD50058
AAD50059
AAD50060
AAH12279
BAB27029
BAB30811
BAE31732
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