InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ddc

Summary

InnateDB Protein

IDBP-261916.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ddc

Protein Name

dopa decarboxylase

Synonyms

Aadc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105286

InnateDB Gene

IDBG-150518 (Ddc)

Protein Structure

UniProt Annotation

Function

Catalyzes the decarboxylation of L-3,4- dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004058	aromatic-L-amino-acid decarboxylase activity
GO:0016597	amino acid binding
GO:0016829	lyase activity
GO:0016831	carboxy-lyase activity
GO:0019904	protein domain specific binding
GO:0030170	pyridoxal phosphate binding

Biological Process

GO:0006520	cellular amino acid metabolic process
GO:0007623	circadian rhythm
GO:0009636	response to toxic substance
GO:0010259	multicellular organismal aging
GO:0015842	synaptic vesicle amine transport
GO:0019752	carboxylic acid metabolic process
GO:0033076	isoquinoline alkaloid metabolic process
GO:0035690	cellular response to drug
GO:0042416	dopamine biosynthetic process
GO:0042427	serotonin biosynthetic process
GO:0046684	response to pyrethroid
GO:0052314	phytoalexin metabolic process
GO:0071312	cellular response to alkaloid
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005737	cytoplasm
GO:0008021	synaptic vesicle
GO:0030424	axon
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:94876

InterPro

IPR001597 Aromatic amino acid beta-eliminating lyase/threonine aldolase
IPR002129 Pyridoxal phosphate-dependent decarboxylase
IPR010977 Aromatic-L-amino-acid decarboxylase
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF01212
PF00282

PRINTS

PR00800

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88533