Version 5.4
Mus musculus Protein: Grb10
Summary
InnateDB Protein IDBP-261931.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Grb10
Protein Name growth factor receptor bound protein 10
Synonyms 5730571D09Rik; AI325020; Meg1; mKIAA0207;
Species Mus musculus
Ensembl Protein ENSMUSP00000105280
InnateDB Gene IDBG-150690 (Grb10)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0042327 positive regulation of phosphorylation
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0048009 insulin-like growth factor receptor signaling pathway
Cellular Component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:103232
InterPro IPR000159 Ras-association
IPR000980 SH2 domain
IPR015042 BPS (Between PH and SH2) domain
IPR029071 Ubiquitin-related domain
PFAM PF00788
PF00017
PF14633
PF08947
PRINTS PR00401
PIRSF
SMART SM00314
SM00252
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q80Z28
UniProt Splice Variant
Entrez Gene 14783
UniGene Mm.469950
RefSeq
MGI ID
MGI Symbol Grb10
OMIM
CCDS
HPRD
IMGT
EMBL AB106541 AL645803 AL663087
GenPept BAC66117

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca