Mus musculus Gene: Grb10 | |||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||
InnateDB Gene | IDBG-150690.6 | ||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||
Gene Symbol | Grb10 | ||||||||||||||||||||||||
Gene Name | growth factor receptor bound protein 10 | ||||||||||||||||||||||||
Synonyms | 5730571D09Rik; AI325020; Meg1; mKIAA0207 | ||||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||||
Ensembl Gene | ENSMUSG00000020176 | ||||||||||||||||||||||||
Encoded Proteins |
growth factor receptor bound protein 10
growth factor receptor bound protein 10
growth factor receptor bound protein 10
growth factor receptor bound protein 10
growth factor receptor bound protein 10
growth factor receptor bound protein 10
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Protein Structure |
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Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||
Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106070:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010] |
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Gene Information | |||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||
Genomic Location | Chromosome 11:11930508-12038683 | ||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||
Band | A1 | ||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||
Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||
REACTOME |
SHC activation pathway
SHC-related events pathway
Signaling by Insulin receptor pathway
Signaling by SCF-KIT pathway
Signal attenuation pathway
Insulin receptor signalling cascade pathway
IRS activation pathway
IRS-related events pathway
Signal Transduction pathway
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KEGG | |||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||||
Pathway Predictions based on Human Orthology Data | |||||||||||||||||||||||||
NETPATH |
EGFR1 pathway
KitReceptor pathway
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REACTOME |
Signal attenuation pathway
IRS activation pathway
SHC activation pathway
Signaling by Insulin receptor pathway
Signaling by SCF-KIT pathway
SHC-related events pathway
Signal Transduction pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
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KEGG | |||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||
PID NCI |
IGF1 pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events regulated by Ret tyrosine kinase
PDGFR-beta signaling pathway
Insulin Pathway
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Cross-References | |||||||||||||||||||||||||
SwissProt | Q60760 | ||||||||||||||||||||||||
TrEMBL | B1ATS7 B1ATS8 Q5SUW0 Q5SUW3 Q80Z28 | ||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||
Entrez Gene | 14783 | ||||||||||||||||||||||||
UniGene | Mm.464229 Mm.469950 | ||||||||||||||||||||||||
RefSeq | NM_001177629 NM_010345 XM_006514528 XM_006514530 | ||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||
CCDS | CCDS24440 CCDS48754 | ||||||||||||||||||||||||
HPRD | |||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||
MGI ID | MGI:103232 | ||||||||||||||||||||||||
MGI Symbol | Grb10 | ||||||||||||||||||||||||
EMBL | AB106541 AF022072 AK030727 AK032927 AK163841 AL645803 AL663087 BC016111 BC053842 U18996 | ||||||||||||||||||||||||
GenPept | AAB53687 AAB72103 AAH16111 AAH53842 BAC27100 BAC28088 BAC66117 BAE37514 CAI23990 CAI23991 CAI25685 CAI25687 | ||||||||||||||||||||||||
RNA Seq Atlas | 14783 | ||||||||||||||||||||||||