Mus musculus Gene: Grb10
Summary
InnateDB Gene IDBG-150690.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Grb10
Gene Name growth factor receptor bound protein 10
Synonyms 5730571D09Rik; AI325020; Meg1; mKIAA0207;
Species Mus musculus
Ensembl Gene ENSMUSG00000020176
Encoded Proteins
growth factor receptor bound protein 10
growth factor receptor bound protein 10
growth factor receptor bound protein 10
growth factor receptor bound protein 10
growth factor receptor bound protein 10
growth factor receptor bound protein 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106070:
The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:11930508-12038683
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000093321 ENSMUSP00000091011
ENSMUST00000109654 ENSMUSP00000105281
ENSMUST00000109653 ENSMUSP00000105280
ENSMUST00000124587
ENSMUST00000148254
ENSMUST00000142877
ENSMUST00000143386 ENSMUSP00000118350
ENSMUST00000150972 ENSMUSP00000119344
ENSMUST00000143915 ENSMUSP00000115160
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0005070 SH3/SH2 adaptor activity
GO:0005158 insulin receptor binding
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0008286 insulin receptor signaling pathway
GO:0009967 positive regulation of signal transduction
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032868 response to insulin
GO:0042326 negative regulation of phosphorylation
GO:0042327 positive regulation of phosphorylation
GO:0045719 negative regulation of glycogen biosynthetic process
GO:0046325 negative regulation of glucose import
GO:0046627 negative regulation of insulin receptor signaling pathway
GO:0048009 insulin-like growth factor receptor signaling pathway
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
SHC activation pathway
SHC-related events pathway
Signaling by Insulin receptor pathway
Signaling by SCF-KIT pathway
Signal attenuation pathway
Insulin receptor signalling cascade pathway
IRS activation pathway
IRS-related events pathway
Signal Transduction pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
KitReceptor pathway
REACTOME
SHC-related events pathway
SHC activation pathway
Signaling by SCF-KIT pathway
Signal Transduction pathway
Insulin receptor signalling cascade pathway
IRS-related events pathway
IRS activation pathway
Signal attenuation pathway
Signaling by Insulin receptor pathway
KEGG
INOH
PID BIOCARTA
PID NCI
IGF1 pathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
Signaling events mediated by VEGFR1 and VEGFR2
Signaling events regulated by Ret tyrosine kinase
PDGFR-beta signaling pathway
Insulin Pathway
Cross-References
SwissProt
TrEMBL B1ATS7 B1ATS8 Q80Z28
UniProt Splice Variant
Entrez Gene 14783
UniGene Mm.464229 Mm.469950
RefSeq NM_001177629 NM_010345 XM_006514528 XM_006514530
OMIM
CCDS CCDS24440 CCDS48754
HPRD
IMGT
MGI ID MGI:103232
MGI Symbol Grb10
EMBL AB106541 AL645803 AL663087
GenPept BAC66117
RNA Seq Atlas 14783