InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Zfp423

Summary

InnateDB Protein

IDBP-261933.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Zfp423

Protein Name

zinc finger protein 423

Synonyms

ataxia1; Ebfaz; mKIAA0760; nur12; Roaz; Zfp104; Znf423;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000105282

InnateDB Gene

IDBG-178353 (Zfp423)

Protein Structure

UniProt Annotation

Function

Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation. {ECO:0000269PubMed:16943432, ECO:0000269PubMed:17151198, ECO:0000269PubMed:17521568, ECO:0000269PubMed:17524391}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Within the cerebellum, Zfp423 is expressed in both ventricular and external germinal zones. Transiently expressed in newly differentiating olfactory-receptor neurons. {ECO:0000269PubMed:16943432, ECO:0000269PubMed:17151198, ECO:0000269PubMed:17521568}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0007219	Notch signaling pathway
GO:0007399	nervous system development
GO:0030154	cell differentiation
GO:0030513	positive regulation of BMP signaling pathway
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated