Version 5.4
Mus musculus Gene: Zfp423
Summary
InnateDB Gene IDBG-178353.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zfp423
Gene Name zinc finger protein 423
Synonyms ataxia1; Ebfaz; mKIAA0760; nur12; Roaz; Zfp104; Znf423
Species Mus musculus
Ensembl Gene ENSMUSG00000045333
Encoded Proteins
IDBP-178355
zinc finger protein 423
IDBP-261933
zinc finger protein 423
IDBP-621301
zinc finger protein 423
IDBP-621304
zinc finger protein 423
IDBP-621305
zinc finger protein 423
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 25554785
The transcription factor Zfp423 is necessary for adipocyte activation and impaired adipogenesis is observed in Zfp423(nur12) mice.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102935:
The protein encoded by this gene is a nuclear protein that belongs to the family of Kruppel-like C2H2 zinc finger proteins. It functions as a DNA-binding transcription factor by using distinct zinc fingers in different signaling pathways. Thus, it is thought that this gene may have multiple roles in signal transduction during development. Mutations in this gene are associated with nephronophthisis-14 and Joubert syndrome-19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:87661810-87959595
Strand Reverse strand
Band C3
Transcripts
ENSMUST00000052250 ENSMUSP00000052379
ENSMUST00000109655 ENSMUSP00000105282
ENSMUST00000165770 ENSMUSP00000129724
ENSMUST00000174764 ENSMUSP00000134575
ENSMUST00000174249 ENSMUSP00000134103
ENSMUST00000173725
ENSMUST00000173092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0007219 Notch signaling pathway
GO:0007399 nervous system development
GO:0030154 cell differentiation
GO:0030513 positive regulation of BMP signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102935
View Gene Order
ENSBTAG00000017397
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt Q80TS5
TrEMBL G3UW89
UniProt Splice Variant
Entrez Gene 94187
UniGene Mm.23452 Mm.472447 Mm.472668
RefSeq NM_033327 XM_006531534 XM_006531535 XM_006531536 XM_006531537 XM_006531538 XM_006531539 XM_006531540
OMIM
CCDS CCDS52627
HPRD
IMGT
MGI ID MGI:1891217
MGI Symbol Zfp423
EMBL AC121809 AC127285 AC171684 AF188609 AK122365 AY147407 AY256893 BC059234 BC139028 BC139030 CH466525
GenPept AAG17053 AAH59234 AAI39029 AAI39031 AAN39840 AAP33073 BAC65647 EDL11044
RNA Seq Atlas 94187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca