Version 5.4
Homo sapiens Protein: FHOD3
Summary
InnateDB Protein IDBP-2622.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FHOD3
Protein Name formin homology 2 domain containing 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000257209
InnateDB Gene IDBG-2618 (FHOD3)
Protein Structure
UniProt Annotation
Function Actin-organizing protein that may cause stress fiber formation together with cell elongation (By similarity). Isoform 4 may play a role in actin filament polymerization in cardiomyocytes. {ECO:0000250, ECO:0000269PubMed:21149568}.
Subcellular Localization Cytoplasm, cytoskeleton {ECO:0000269PubMed:21149568}. Note=Main part of the protein localizes to actin fibers and the remaining part displays filamentous staining. {ECO:0000250}.Isoform 4: Cytoplasm, myofibril, sarcomere, Z line. Note=Threonine phosphorylation in isoform 4-specific sequence TDTDEEEEVE is required for targeting to myofibrils in cardiomyocytes.
Disease Associations
Tissue Specificity Expressed in the heart, kidney and brain. May be down-regulated in various types of heart diseases, including idiopathic dilated, ventricular dilated, familial dilated and perinatal dilated cardiomyopathies, as well as ischemic heart disease (at protein level). {ECO:0000269PubMed:15966898, ECO:0000269PubMed:21149568}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005488 binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0030018 Z disc
Protein Structure and Domains
PDB ID
InterPro IPR015425 Formin, FH2 domain
IPR016024 Armadillo-type fold
PFAM PF02181
PRINTS
PIRSF
SMART SM00498
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2V2M9
PhosphoSite PhosphoSite-Q2V2M9
TrEMBL
UniProt Splice Variant
Entrez Gene 80206
UniGene Hs.630884
RefSeq NP_079411
HUGO HGNC:26178
OMIM 609691
CCDS CCDS32816
HPRD 16894
IMGT
EMBL AB051482 AB084087 AC023043 AC055840 AC090333 AC131053 AK025950 AK026370 AK128053 AL834480 BC050670 BC081563 HM191478
GenPept AAH50670 AAH81563 ADL62709 BAB15292 BAB15463 BAB21786 BAC67014 BAC87252 CAD39139

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca