InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scn8a

Summary

InnateDB Protein

IDBP-263547.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scn8a

Protein Name

sodium channel, voltage-gated, type VIII, alpha

Synonyms

AI853486; C630029C19Rik; dmu; med; mnd-2; mnd2; NaCh6; Nav1.6; nmf2; nmf335; nmf58; nur14; seal;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104538

InnateDB Gene

IDBG-185291 (Scn8a)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0007517	muscle organ development
GO:0007605	sensory perception of sound
GO:0007626	locomotory behavior
GO:0007628	adult walking behavior
GO:0008344	adult locomotory behavior
GO:0009636	response to toxic substance
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0050905	neuromuscular process
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030425	dendrite
GO:0034706	sodium channel complex
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:103169

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001696 Voltage gated sodium channel, alpha subunit
IPR003915 Polycystic kidney disease type 2 protein
IPR005821 Ion transport domain
IPR008054 Voltage gated sodium channel, alpha-8 subunit
IPR010526 Sodium ion transport-associated
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR024583 Domain of unknown function DUF3451
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00520
PF06512
PF08016
PF11933

PRINTS

PR00170
PR01433
PR01667

PIRSF

SMART

SM00015

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt