InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rgs19

Summary

InnateDB Protein

IDBP-263805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rgs19

Protein Name

regulator of G-protein signaling 19

Synonyms

2610042F04Rik; AI324841; AW547781; GAIP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104406

InnateDB Gene

IDBG-214217 (Rgs19)

Protein Structure

UniProt Annotation

Function

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001965	G-protein alpha-subunit binding
GO:0005096	GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043547	positive regulation of GTPase activity

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005903	brush border
GO:0030136	clathrin-coated vesicle

Protein Structure and Domains

PDB ID

MGI:1915153

InterPro

IPR000342 Regulator of G protein signalling domain
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615

PRINTS

PR01301

PIRSF

SMART

SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9CX84

PhosphoSite

PhosphoSite-Q9CX84

TrEMBL

Q9CTC4

UniProt Splice Variant

Entrez Gene

56470

UniGene

Mm.274366

RefSeq

NP_001278138

MGI ID

MGI Symbol

Rgs19

OMIM

CCDS

CCDS17220

HPRD

IMGT

EMBL

AF535869 AF535870 AK003967 AK019401 AK042531 AK154844 AL844529 AL845173 AY138504 BC003838

GenPept

AAH03838 AAN78095 AAN78096 AAO16180 AAO16181 BAB23098 BAB31703 BAC31284 BAE32870