InnateDB Protein
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IDBP-264040.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ndel1
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Protein Name
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nuclear distribution gene E-like homolog 1 (A. nidulans)
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Synonyms
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2600006O07Rik; MITAP1; mNudel; NUDEL;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000104312
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InnateDB Gene
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IDBG-189118 (Ndel1)
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Protein Structure
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Function |
Required for organization of the cellular microtubule array and microtubule anchoring at the centrosome. May regulate microtubule organization at least in part by targeting the microtubule severing protein KATNA1 to the centrosome. Also positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus ends. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the centripetal motion of secretory vesicles and the coupling of the nucleus and centrosome. Also required during brain development for the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Plays a role, together with DISC1, in the regulation of neurite outgrowth. Required for mitosis in some cell types but appears to be dispensible for mitosis in cortical neuronal progenitors, which instead requires NDE1. Facilitates the polymerization of neurofilaments from the individual subunits NEFH and NEFL. {ECO:0000269PubMed:12796778, ECO:0000269PubMed:15208636, ECO:0000269PubMed:15473966, ECO:0000269PubMed:16107726, ECO:0000269PubMed:16203747}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore {ECO:0000250}. Cytoplasm, cytoskeleton, spindle. Note=Localizes to the kinetochore in a CENPF-dependent manner. Colocalizes with DISC1 in the perinuclear region, including the centrosome (By similarity). Localizes to the interphase centrosome and the mitotic spindle. Localizes to the cell body of the motor neurons and colocalizes with assembled neurofilaments within axonal processes. Localizes to the microtubules of the manchette in elongated spermatids. Localizes to the interphase centrosome and the mitotic spindle. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Expressed in brain, liver, lung and testis (at protein level). Expressed in brain, epididymis, eye, heart, kidney, large intestine, liver, ovary, pancreas, prostate, skeletal muscle, smooth muscle, spleen, submaxillary gland, testis, thymus and thyroid. Within the brain expression is pronounced in the cortex, hippocampus, olfactory bulb, striatum, thalamic and hypothalamic structures and in the molecular layer of the cerebellum. Largely excluded from cortical progenitor cells which express NDE1. {ECO:0000269PubMed:11163259, ECO:0000269PubMed:11163260, ECO:0000269PubMed:11231056, ECO:0000269PubMed:15147871}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
24
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
40 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1932915
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InterPro |
IPR006964
NUDE protein, C-terminal
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PFAM |
PF04880
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9ERR1
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PhosphoSite |
PhosphoSite-Q9ERR1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
83431
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UniGene |
Mm.470454
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RefSeq |
XP_006534601
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MGI ID |
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MGI Symbol |
Ndel1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AF290472
AF323918
AK011168
AL603662
BC021434
BC046796
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GenPept |
AAG10061
AAG42496
AAH21434
AAH46796
BAB27443
CAI25525
CAI25526
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