InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prpf31

Summary

InnateDB Protein

IDBP-264114.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Prpf31

Protein Name

PRP31 pre-mRNA processing factor 31 homolog (yeast)

Synonyms

1500019O16Rik; 2810404O06Rik; AW554706; PRP31; RP11;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104276

InnateDB Gene

IDBG-135774 (Prpf31)

Protein Structure

UniProt Annotation

Function

Involved in pre-mRNA splicing. Required for the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus speckle {ECO:0000250}. Nucleus, Cajal body {ECO:0000250}. Note=Predominantly found in speckles and in Cajal bodies. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	9 [view]
Protein-Protein	9 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0043021	ribonucleoprotein complex binding
GO:0070990	snRNP binding

Biological Process

GO:0000244	spliceosomal tri-snRNP complex assembly
GO:0000398	mRNA splicing, via spliceosome

Cellular Component

GO:0005681	spliceosomal complex
GO:0005687	U4 snRNP
GO:0015030	Cajal body
GO:0016607	nuclear speck
GO:0046540	U4/U6 x U5 tri-snRNP complex
GO:0071339	MLL1 complex