Mus musculus Protein: Eif5a | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-264172.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Eif5a | ||||||||||||||||||||||
Protein Name | eukaryotic translation initiation factor 5A | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000104249 | ||||||||||||||||||||||
InnateDB Gene | IDBG-264162 (Eif5a) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}. | ||||||||||||||||||||||
Subcellular Localization | Cytoplasm {ECO:0000269PubMed:17707773}. Nucleus {ECO:0000269PubMed:17707773}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=The N-terminal extension contributes in signaling this protein to nuclear localization. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | |||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:106248 | ||||||||||||||||||||||
InterPro |
IPR001884
Translation elongation factor IF5A IPR005824 KOW IPR008991 Translation protein SH3-like domain IPR012340 Nucleic acid-binding, OB-fold IPR020189 Translation elongation factor, IF5A C-terminal |
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PFAM |
PF00467
PF01287 |
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PRINTS | |||||||||||||||||||||||
PIRSF |
PIRSF003025
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SMART |
SM00739
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P63242 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P63242 | ||||||||||||||||||||||
TrEMBL | J3QPS8 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 276770 | ||||||||||||||||||||||
UniGene | |||||||||||||||||||||||
RefSeq | XP_006533529 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Eif5a | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS24923 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AK011306 AK011470 AK149705 AL596185 AY129323 AY129324 AY129325 AY129326 AY129327 AY129328 AY129329 BC003889 BC008093 BC024899 | ||||||||||||||||||||||
GenPept | AAH03889 AAH08093 AAH24899 AAN17521 AAN17527 AAN17528 AAN17532 AAN17534 AAN17535 AAN17539 BAB27532 BAB27641 BAE29039 CAI35153 CAI35154 | ||||||||||||||||||||||