Mus musculus Gene: Eif5a
Summary
InnateDB Gene IDBG-264162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Eif5a
Gene Name eukaryotic translation initiation factor 5A
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000078812
Encoded Proteins
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
eukaryotic translation initiation factor 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an elongation initiation factor, which participates in protein synthesis. The encoded protein also plays roles in mRNA metabolism, cell proliferation, and cell cycle control. This protein contains a modified lysine residue called hypusine, which appears to be necessary for its function. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2, 5, and 19. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:69916714-69921958
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000071026 ENSMUSP00000068651
ENSMUST00000043419 ENSMUSP00000047008
ENSMUST00000070996 ENSMUSP00000067077
ENSMUST00000108613 ENSMUSP00000104253
ENSMUST00000108612 ENSMUSP00000104252
ENSMUST00000108611 ENSMUSP00000104251
ENSMUST00000108610 ENSMUSP00000104250
ENSMUST00000108609 ENSMUSP00000104249
ENSMUST00000108608 ENSMUSP00000104248
ENSMUST00000108607 ENSMUSP00000104247
ENSMUST00000153652 ENSMUSP00000137459
ENSMUST00000152589 ENSMUSP00000123402
ENSMUST00000164359 ENSMUSP00000132717
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0043022 ribosome binding
Biological Process
GO:0006452 translational frameshifting
GO:0007568 aging
GO:0008612 peptidyl-lysine modification to peptidyl-hypusine
GO:0015031 protein transport
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045901 positive regulation of translational elongation
GO:0045905 positive regulation of translational termination
GO:0051028 mRNA transport
GO:0051149 positive regulation of muscle cell differentiation
Cellular Component
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0030425 dendrite
GO:0043025 neuronal cell body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Metabolism of proteins pathway
Post-translational protein modification pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
Hypusine synthesis from eIF5A-lysine pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Hypusine synthesis from eIF5A-lysine pathway
Metabolism of proteins pathway
Post-translational protein modification pathway
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt P63242
TrEMBL J3QPS8
UniProt Splice Variant
Entrez Gene 276770
UniGene
RefSeq NM_001166589 NM_001166590 NM_001166591 NM_001166592 NM_001166593 NM_001166594 NM_001166595 NM_001166596 NM_181582
OMIM
CCDS CCDS24923
HPRD
IMGT
MGI ID MGI:106248
MGI Symbol Eif5a
EMBL AK011306 AK011470 AK149705 AL596185 AY129323 AY129324 AY129325 AY129326 AY129327 AY129328 AY129329 BC003889 BC008093 BC024899
GenPept AAH03889 AAH08093 AAH24899 AAN17521 AAN17527 AAN17528 AAN17532 AAN17534 AAN17535 AAN17539 BAB27532 BAB27641 BAE29039 CAI35153 CAI35154
RNA Seq Atlas 276770