InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Eif5a

Summary

InnateDB Protein

IDBP-264174.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Eif5a

Protein Name

eukaryotic translation initiation factor 5A

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104248

InnateDB Gene

IDBG-264162 (Eif5a)

Protein Structure

UniProt Annotation

Function

mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis. Regulates also TNF- alpha-mediated apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17707773}. Nucleus {ECO:0000269PubMed:17707773}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=The N-terminal extension contributes in signaling this protein to nuclear localization.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003746	translation elongation factor activity
GO:0043022	ribosome binding

Biological Process

GO:0006452	translational frameshifting
GO:0007568	aging
GO:0008612	peptidyl-lysine modification to peptidyl-hypusine
GO:0015031	protein transport
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0045901	positive regulation of translational elongation
GO:0045905	positive regulation of translational termination
GO:0051028	mRNA transport
GO:0051149	positive regulation of muscle cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0030425	dendrite
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:106248

InterPro

IPR001884 Translation elongation factor IF5A
IPR005824 KOW
IPR008991 Translation protein SH3-like domain
IPR012340 Nucleic acid-binding, OB-fold
IPR020189 Translation elongation factor, IF5A C-terminal

PFAM

PF00467
PF01287

PRINTS

PIRSF

PIRSF003025

SMART

SM00739

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt