Version 5.4
Mus musculus Protein: Ybx2
Summary
InnateDB Protein IDBP-264188.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ybx2
Protein Name Y box protein 2
Synonyms Msy2;
Species Mus musculus
Ensembl Protein ENSMUSP00000104242
InnateDB Gene IDBG-192820 (Ybx2)
Protein Structure
UniProt Annotation
Function Major constituent of messenger ribonucleoprotein particles (mRNPs). Involved in the regulation of the stability and/or translation of germ cell mRNAs. Binds to Y-box consensus promoter element. Binds to full length mRNA with high affinity in a sequence-independent manner. Binds to short RNA sequences containing the consensus site 5'-UCCAUCA-3' with low affinity and limited sequence specificity. Its binding with maternal mRNAs is necessary for its cytoplasmic retention. May mark specific mRNAs (those transcribed from Y-box promoters) in the nucleus for cytoplasmic storage, thereby linking transcription and mRNA storage/translational delay. {ECO:0000269PubMed:10076007, ECO:0000269PubMed:12297523, ECO:0000269PubMed:12648488, ECO:0000269PubMed:15031116, ECO:0000269PubMed:15665108}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:11566752}. Nucleus {ECO:0000269PubMed:11566752}.
Disease Associations
Tissue Specificity Expressed in meiotic and postmeiotic male germ cells and oocytes; poorly expressed in two cell stage embryos (at protein level). Not detected in preimplantation embryos. {ECO:0000269PubMed:11566752, ECO:0000269PubMed:9780336}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003729 mRNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0008289 lipid binding
GO:0043021 ribonucleoprotein complex binding
GO:0045182 translation regulator activity
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0007286 spermatid development
GO:0017148 negative regulation of translation
GO:0048255 mRNA stabilization
GO:0048477 oogenesis
GO:0048599 oocyte development
GO:0051100 negative regulation of binding
Cellular Component
GO:0005737 cytoplasm
GO:0005844 polysome
GO:0030529 ribonucleoprotein complex
Protein Structure and Domains
PDB ID MGI:1096372
InterPro IPR002059 Cold-shock protein, DNA-binding
IPR011129 Cold shock protein
IPR012340 Nucleic acid-binding, OB-fold
PFAM PF00313
PRINTS PR00050
PIRSF
SMART SM00357
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3TTC8
UniProt Splice Variant
Entrez Gene 53422
UniGene Mm.29286
RefSeq XP_006533803
MGI ID
MGI Symbol Ybx2
OMIM
CCDS
HPRD
IMGT
EMBL AK161439 AL596185
GenPept BAE36397

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca