InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Myo1c

Summary

InnateDB Protein

IDBP-264559.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo1c

Protein Name

myosin IC

Synonyms

C80397; mm1beta; MMIb; MYO1E; myr2; NMI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000104069

InnateDB Gene

IDBG-200373 (Myo1c)

Protein Structure

UniProt Annotation

Function

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.

Subcellular Localization

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium membrane. Cytoplasmic vesicle. Cell projection, ruffle. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 at actin-based membranes. Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm.Isoform 3: Nucleus, nucleolus. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level (By similarity). Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 3 is expressed in small intestine, pancreas, brain, kidney, skin, heart muscle, testis, striated muscle, spleen, liver and lung (at protein level). Expressed in brain, testis, adrenal glands, thymus, spleen, kidney, lung, heart, cochlea and vestibule. Expressed in sensory hair cells of the inner ear. Expressed in adipocytes. {ECO:0000269PubMed:12490950, ECO:0000269PubMed:16102537, ECO:0000269PubMed:16957816, ECO:0000269PubMed:9119401}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0008022	protein C-terminus binding
GO:0030898	actin-dependent ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006605	protein targeting
GO:0006612	protein targeting to membrane
GO:0006810	transport
GO:0008152	metabolic process
GO:0030335	positive regulation of cell migration
GO:0038089	positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0051028	mRNA transport
GO:0090314	positive regulation of protein targeting to membrane
GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway
GO:2000810	regulation of tight junction assembly

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005903	brush border
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016328	lateral plasma membrane
GO:0016459	myosin complex
GO:0031941	filamentous actin
GO:0032420	stereocilium
GO:0045121	membrane raft
GO:0045160	myosin I complex
GO:0060171	stereocilium membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:106612

InterPro

IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR010926 Myosin tail 2
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00612
PF00063
PF06017

PRINTS

PR00193

PIRSF

SMART

SM00015
SM00242

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt