Mus musculus Protein: Myo1c
InnateDB Protein IDBP-264559.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Myo1c
Protein Name myosin IC
Synonyms C80397; mm1beta; MMIb; MYO1E; myr2; NMI;
Species Mus musculus
Ensembl Protein ENSMUSP00000104069
InnateDB Gene IDBG-200373 (Myo1c)
Protein Structure
UniProt Annotation
Function Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails bind to membranous compartments, which then are moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.
Subcellular Localization Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, stereocilium membrane. Cytoplasmic vesicle. Cell projection, ruffle. Note=Colocalizes with CABP1 and CIB1 at cell margin, membrane ruffles and punctate regions on the cell membrane. Colocalizes in adipocytes with GLUT4 at actin-based membranes. Colocalizes with GLUT4 at insulin-induced ruffles at the cell membrane. Localizes transiently at cell membrane to region known to be enriched in PIP2. Activation of phospholipase C results in its redistribution to the cytoplasm.Isoform 3: Nucleus, nucleolus. Nucleus, nucleoplasm {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level (By similarity). Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli. {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform 3 is expressed in small intestine, pancreas, brain, kidney, skin, heart muscle, testis, striated muscle, spleen, liver and lung (at protein level). Expressed in brain, testis, adrenal glands, thymus, spleen, kidney, lung, heart, cochlea and vestibule. Expressed in sensory hair cells of the inner ear. Expressed in adipocytes. {ECO:0000269PubMed:12490950, ECO:0000269PubMed:16102537, ECO:0000269PubMed:16957816, ECO:0000269PubMed:9119401}.
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
Predicted by orthology
Total 41 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003774 motor activity
GO:0003779 actin binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0005543 phospholipid binding
GO:0008022 protein C-terminus binding
GO:0030898 actin-dependent ATPase activity
Biological Process
GO:0006200 ATP catabolic process
GO:0006605 protein targeting
GO:0006612 protein targeting to membrane
GO:0006810 transport
GO:0008152 metabolic process
GO:0030335 positive regulation of cell migration
GO:0038089 positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0051028 mRNA transport
GO:0090314 positive regulation of protein targeting to membrane
GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway
GO:2000810 regulation of tight junction assembly
Cellular Component
GO:0001726 ruffle
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005902 microvillus
GO:0005903 brush border
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016328 lateral plasma membrane
GO:0016459 myosin complex
GO:0031941 filamentous actin
GO:0032420 stereocilium
GO:0045121 membrane raft
GO:0045160 myosin I complex
GO:0060171 stereocilium membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:106612
InterPro IPR000048 IQ motif, EF-hand binding site
IPR001609 Myosin head, motor domain
IPR010926 Myosin tail 2
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00612
Post-translational Modifications
SwissProt Q9WTI7
PhosphoSite PhosphoSite-Q9WTI7
UniProt Splice Variant
Entrez Gene 17913
UniGene Mm.413478
RefSeq NP_001074244
MGI Symbol Myo1c
EMBL AK004743 AK154294 AK155530 AK171107 AL591440 AY007255 BC021481 CF615767 CH466596 U96723 U96726 X99638
GenPept AAC53264 AAC60758 AAG02570 AAH21481 BAB23524 BAE32495 BAE33311 BAE42253 CAA67956 CAI24085 CAI24086 CAI24088 EDL12832 EDL12833