InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Myo1c

Summary

InnateDB Gene

IDBG-200373.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Myo1c

Gene Name

myosin IC

Synonyms

C80397; mm1beta; MMIb; MYO1E; myr2; NMI

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017774

Encoded Proteins

IDBP-200375

myosin IC

IDBP-200379

myosin IC

IDBP-200381

myosin IC

IDBP-264559

myosin IC

IDBP-531752

myosin IC

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The protein functions in intracellular vesicle transport to the plasma membrane. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:75650504-75673910

Strand

Forward strand

Band

Transcripts

ENSMUST00000102505	ENSMUSP00000099563
ENSMUST00000069057	ENSMUSP00000070388
ENSMUST00000102504	ENSMUSP00000099562
ENSMUST00000108431	ENSMUSP00000104069
ENSMUST00000151174
ENSMUST00000136935	ENSMUSP00000121267
ENSMUST00000148659
ENSMUST00000123064
ENSMUST00000146419
ENSMUST00000155027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	13 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003774	motor activity
GO:0003779	actin binding
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0005543	phospholipid binding
GO:0008022	protein C-terminus binding
GO:0030898	actin-dependent ATPase activity

Biological Process

GO:0006200	ATP catabolic process
GO:0006605	protein targeting
GO:0006612	protein targeting to membrane
GO:0006810	transport
GO:0008152	metabolic process
GO:0030335	positive regulation of cell migration
GO:0038089	positive regulation of cell migration by vascular endothelial growth factor signaling pathway
GO:0051028	mRNA transport
GO:0090314	positive regulation of protein targeting to membrane
GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway
GO:2000810	regulation of tight junction assembly

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005902	microvillus
GO:0005903	brush border
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016328	lateral plasma membrane
GO:0016459	myosin complex
GO:0031941	filamentous actin
GO:0032420	stereocilium
GO:0045121	membrane raft
GO:0045160	myosin I complex
GO:0060171	stereocilium membrane
GO:0070062	extracellular vesicular exosome