Version 5.4
Mus musculus Protein: Ints8
Summary
InnateDB Protein IDBP-264785.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ints8
Protein Name integrator complex subunit 8
Synonyms 2810013E07Rik; AV063769; D130008D20Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000103955
InnateDB Gene IDBG-129327 (Ints8)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID MGI:1919906
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80V86
PhosphoSite PhosphoSite-Q80V86
TrEMBL
UniProt Splice Variant
Entrez Gene 72656
UniGene Mm.246713
RefSeq NP_001153067
MGI ID
MGI Symbol Ints8
OMIM
CCDS CCDS17967
HPRD
IMGT
EMBL AK012736 AK049513 AK140829 AK164951 AK169552 AL840625 BC049092 BC050192 BC057618
GenPept AAH49092 AAH50192 AAH57618 BAC25374 BAC33786 BAE24491 BAE37977 BAE41225 CAM21623

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca