Version 5.4
Mus musculus Gene: Ints8
Summary
InnateDB Gene IDBG-129327.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ints8
Gene Name integrator complex subunit 8
Synonyms 2810013E07Rik; AV063769; D130008D20Rik
Species Mus musculus
Ensembl Gene ENSMUSG00000040738
Encoded Proteins
IDBP-129329
integrator complex subunit 8
IDBP-264785
integrator complex subunit 8
IDBP-264787
integrator complex subunit 8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164941:
This gene encodes a subunit of the Integrator complex which is involved in the cleavage of small nuclear RNAs U1 and U2 within the nucleus. The encoded protein associates with RNA polymerase II and is recruited to the U1 and U2 small nuclear RNA genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:11199158-11254258
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000044616 ENSMUSP00000038418
ENSMUST00000108319 ENSMUSP00000103955
ENSMUST00000108318 ENSMUSP00000103954
ENSMUST00000136545
ENSMUST00000137054
ENSMUST00000145252
ENSMUST00000133031
ENSMUST00000147372
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0032039 integrator complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000164941
View Gene Order
ENSBTAG00000004902
Not yet available
Cross-References
SwissProt Q80V86
TrEMBL
UniProt Splice Variant
Entrez Gene 72656
UniGene Mm.246713
RefSeq NM_178112 XM_006538278 NM_001159595
OMIM
CCDS CCDS17967
HPRD
IMGT
MGI ID MGI:1919906
MGI Symbol Ints8
EMBL AK012736 AK049513 AK140829 AK164951 AK169552 AL840625 BC049092 BC050192 BC057618
GenPept AAH49092 AAH50192 AAH57618 BAC25374 BAC33786 BAE24491 BAE37977 BAE41225 CAM21623
RNA Seq Atlas 72656

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca