Version 5.4
Mus musculus Protein: Ints2
Summary
InnateDB Protein IDBP-265379.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ints2
Protein Name integrator complex subunit 2
Synonyms 2810417D08Rik; AA408260; AI987735; mKIAA1287;
Species Mus musculus
Ensembl Protein ENSMUSP00000103674
InnateDB Gene IDBG-206795 (Ints2)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0016180 snRNA processing
Cellular Component
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID MGI:1917672
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q80UK8
PhosphoSite PhosphoSite-Q80UK8
TrEMBL X1WI16
UniProt Splice Variant
Entrez Gene 70422
UniGene Mm.440906
RefSeq
MGI ID
MGI Symbol Ints2
OMIM
CCDS CCDS25198
HPRD
IMGT
EMBL AK013101 AK037055 AK129323 AK164097 AL592065 BC050081 BC059056
GenPept AAH50081 AAH59056 BAB28647 BAC29686 BAC98133 BAE37627 CAI25864 CAI25865 CAI25866

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca