InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Spop

Summary

InnateDB Protein

IDBP-266061.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Spop

Protein Name

speckle-type POZ protein

Synonyms

AI315626; Pcif1; TEF2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103350

InnateDB Gene

IDBG-209590 (Spop)

Protein Structure

UniProt Annotation

Function

Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL (By similarity). In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1; this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. {ECO:0000250, ECO:0000269PubMed:15121856, ECO:0000269PubMed:16740475, ECO:0000269PubMed:20463034, ECO:0000269PubMed:20811152}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15121856}. Nucleus speckle {ECO:0000269PubMed:15121856}.

Disease Associations

Tissue Specificity

Widely expressed, mainly in pancreas and in particular in adult pancreatic insulin-producing beta cells and in a subset of exocrine acinar and duct cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	7 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	26 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001085	RNA polymerase II transcription factor binding
GO:0005515	protein binding

Biological Process

GO:0042593	glucose homeostasis
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902237	positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000676	positive regulation of type B pancreatic cell apoptotic process