Version 5.4
Mus musculus Gene: Spop
Summary
InnateDB Gene IDBG-209590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spop
Gene Name speckle-type POZ protein
Synonyms AI315626; Pcif1; TEF2
Species Mus musculus
Ensembl Gene ENSMUSG00000057522
Encoded Proteins
IDBP-266059
speckle-type POZ protein
IDBP-266061
speckle-type POZ protein
IDBP-533077
speckle-type POZ protein
IDBP-538074
speckle-type POZ protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000121067:
This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:95414080-95493406
Strand Forward strand
Band D
Transcripts
ENSMUST00000107724 ENSMUSP00000103352
ENSMUST00000107722 ENSMUSP00000103350
ENSMUST00000150884 ENSMUSP00000119650
ENSMUST00000127713 ENSMUSP00000118922
ENSMUST00000150922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 26 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 26 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001085 RNA polymerase II transcription factor binding
GO:0005515 protein binding
Biological Process
GO:0042593 glucose homeostasis
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:1902237 positive regulation of intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:2000676 positive regulation of type B pancreatic cell apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
GO:0031463 Cul3-RING ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000121067
View Gene Order
ENSBTAG00000005824
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
hedgehog_glipathway
Hedgehog signaling events mediated by Gli proteins
Cross-References
SwissProt
TrEMBL B1ATK7
UniProt Splice Variant
Entrez Gene 20747
UniGene Mm.285454
RefSeq NM_025287 XM_006532692
OMIM
CCDS CCDS36286
HPRD
IMGT
MGI ID MGI:1343085
MGI Symbol Spop
EMBL AL662875
GenPept
RNA Seq Atlas 20747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca