InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tph1

Summary

InnateDB Protein

IDBP-266165.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tph1

Protein Name

tryptophan hydroxylase 1

Synonyms

Tph;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103296

InnateDB Gene

IDBG-186197 (Tph1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004510	tryptophan 5-monooxygenase activity
GO:0005506	iron ion binding
GO:0016597	amino acid binding
GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

Biological Process

GO:0007623	circadian rhythm
GO:0008152	metabolic process
GO:0009072	aromatic amino acid family metabolic process
GO:0030279	negative regulation of ossification
GO:0035902	response to immobilization stress
GO:0042427	serotonin biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0046849	bone remodeling
GO:0055114	oxidation-reduction process
GO:0060749	mammary gland alveolus development

Cellular Component

GO:0043005

neuron projection

Protein Structure and Domains

PDB ID

MGI:98796

InterPro

IPR002912 ACT domain
IPR005963 Tryptophan 5-monooxygenase
IPR019773 Tyrosine 3-monooxygenase-like
IPR019774 Aromatic amino acid hydroxylase, C-terminal

PFAM

PF01842
PF00351

PRINTS

PR00372

PIRSF

PIRSF000336

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt