Version 5.4
Mus musculus Protein: Sh3d19
Summary
InnateDB Protein IDBP-266187.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh3d19
Protein Name SH3 domain protein D19
Synonyms AW011754; Kryn;
Species Mus musculus
Ensembl Protein ENSMUSP00000103291
InnateDB Gene IDBG-155808 (Sh3d19)
Protein Structure
UniProt Annotation
Function May play a role in regulating A disintegrin and metalloproteases (ADAMs) in the signaling of EGFR-ligand shedding. May be involved in suppression of Ras-induced cellular transformation and Ras-mediated activation of ELK1. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in hair follicles. {ECO:0000269PubMed:12615363}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0070064 proline-rich region binding
Biological Process
GO:0007010 cytoskeleton organization
GO:0022604 regulation of cell morphogenesis
GO:0051044 positive regulation of membrane protein ectodomain proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:1350923
InterPro IPR001452 SH3 domain
IPR011511 Variant SH3 domain
PFAM PF00018
PF14604
PF07653
PRINTS PR00452
PIRSF
SMART SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q91X43
PhosphoSite PhosphoSite-Q91X43
TrEMBL
UniProt Splice Variant
Entrez Gene 27059
UniGene Mm.406736
RefSeq NP_001075883
MGI ID
MGI Symbol Sh3d19
OMIM
CCDS CCDS38469
HPRD
IMGT
EMBL AC133508 AF003234 AK050185 BC012633 BC031117 D89677
GenPept AAB82091 AAH12633 AAH31117 BAA19686 BAC34114

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca