InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CX3CR1

Summary

InnateDB Protein

IDBP-26649.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CX3CR1

Protein Name

chemokine (C-X3-C motif) receptor 1

Synonyms

CCRL1; CMKBRL1; CMKDR1; GPR13; GPRV28; V28;

Species

Homo sapiens

Ensembl Protein

ENSP00000351059

InnateDB Gene

IDBG-26647 (CX3CR1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004896	cytokine receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004950	chemokine receptor activity
GO:0005515	protein binding
GO:0016495	C-X3-C chemokine receptor activity

Biological Process

GO:0002282	microglial cell activation involved in immune response
GO:0006935	chemotaxis
GO:0006968	cellular defense response
GO:0007155	cell adhesion
GO:0007186	G-protein coupled receptor signaling pathway
GO:0009611	response to wounding
GO:0016032	viral process
GO:0016525	negative regulation of angiogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0021795	cerebral cortex cell migration
GO:0030336	negative regulation of cell migration
GO:0045766	positive regulation of angiogenesis
GO:0048246	macrophage chemotaxis
GO:0070098	chemokine-mediated signaling pathway
GO:0071222	cellular response to lipopolysaccharide
GO:0071560	cellular response to transforming growth factor beta stimulus
GO:2001240	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0032809	neuronal cell body membrane
GO:0043005	neuron projection
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000355 Chemokine receptor family
IPR001277 CXC chemokine receptor 4
IPR005384 Duffy antigen/chemokine receptor
IPR005387 CX3C chemokine receptor 1
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00657
PR00645
PR01559
PR01562

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P49238