InnateDB Protein
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IDBP-266628.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Cdc26
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Protein Name
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cell division cycle 26
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Synonyms
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2010012C09Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000103083
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InnateDB Gene
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IDBG-153053 (Cdc26)
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Protein Structure
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Function |
Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
18 [view]
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|
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Molecular Function |
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Biological Process |
GO:0007067
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mitotic nuclear division
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GO:0030071
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regulation of mitotic metaphase/anaphase transition
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GO:0031145
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anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
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GO:0070979
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protein K11-linked ubiquitination
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Cellular Component |
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PDB ID |
MGI:1913690
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InterPro |
IPR018860
Anaphase-promoting complex, subunit CDC26
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PFAM |
PF10471
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q99JP4
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PhosphoSite |
PhosphoSite-Q99JP4
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
66440
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UniGene |
Mm.487307
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RefSeq |
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MGI ID |
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MGI Symbol |
Cdc26
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OMIM |
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CCDS |
CCDS38774
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HPRD |
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IMGT |
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EMBL |
AK012627
BC005775
BC114350
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GenPept |
AAH05775
AAI14351
BAC25372
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