Version 5.4
Mus musculus Gene: Cdc26
Summary
InnateDB Gene IDBG-153053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc26
Gene Name cell division cycle 26
Synonyms 2010012C09Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000066149
Encoded Proteins
IDBP-153055
cell division cycle 26
IDBP-266628
cell division cycle 26
IDBP-541534
cell division cycle 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176386:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:62383654-62408642
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000084525 ENSMUSP00000081573
ENSMUST00000107459 ENSMUSP00000103083
ENSMUST00000134727 ENSMUSP00000120496
ENSMUST00000156854
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005680 anaphase-promoting complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
ENSG00000176386
View Gene Order
Ortholuge
SSD Ortholog
Ortholog supports species divergence
ENSBTAG00000014430
Not yet available
Ortholuge
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
REACT_215601
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_236645
Class I MHC mediated antigen processing & presentation pathway
REACT_222875
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_207679
Separation of Sister Chromatids pathway
REACT_188957
Cellular responses to stress pathway
REACT_222604
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_188804
Cell Cycle pathway
REACT_244364
APC/C-mediated degradation of cell cycle proteins pathway
REACT_230745
Immune System pathway
REACT_241408
M Phase pathway
REACT_256025
Cell Cycle Checkpoints pathway
REACT_199115
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_188820
Cellular Senescence pathway
REACT_246476
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_226135
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_225686
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_254995
Regulation of mitotic cell cycle pathway
REACT_219897
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_205250
Phosphorylation of the APC/C pathway
REACT_206033
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_248037
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_229531
Adaptive Immune System pathway
REACT_234036
Mitotic Spindle Checkpoint pathway
REACT_202512
Mitotic Anaphase pathway
REACT_263475
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_210462
APC/C:Cdc20 mediated degradation of Cyclin B pathway
KEGG
mmu04110
Cell cycle pathway
mmu04114
Oocyte meiosis pathway
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04914
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_6867
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6820
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_1041
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_6871
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_6785
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_1072
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_115566
Cell Cycle pathway
REACT_75774
Adaptive Immune System pathway
REACT_2137
Mitotic Spindle Checkpoint pathway
REACT_6900
Immune System pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_1275
Mitotic Anaphase pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6904
Phosphorylation of the APC/C pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_213075
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_216366
M Phase pathway
REACT_216181
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_212887
Separation of Sister Chromatids pathway
REACT_206069
Cellular responses to stress pathway
REACT_215084
Mitotic Metaphase and Anaphase pathway
REACT_211185
Mitotic Anaphase pathway
REACT_222622
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_209611
Phosphorylation of the APC/C pathway
REACT_214934
Cell Cycle pathway
REACT_215025
Cellular Senescence pathway
REACT_202159
Mitotic Spindle Checkpoint pathway
REACT_202818
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
REACT_218686
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_212154
Regulation of mitotic cell cycle pathway
REACT_218054
APC/C-mediated degradation of cell cycle proteins pathway
REACT_218125
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
REACT_220866
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_203215
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_224819
Cell Cycle Checkpoints pathway
REACT_208116
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_204829
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
REACT_205339
APC/C:Cdc20 mediated degradation of Securin pathway
KEGG
hsa04110
Cell cycle pathway
hsa04114
Oocyte meiosis pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04914
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q99JP4
TrEMBL
UniProt Splice Variant
Entrez Gene 66440
UniGene Mm.390677 Mm.398297 Mm.487307
RefSeq XM_006538173 NM_139291
OMIM
CCDS CCDS38774
HPRD
IMGT
MGI ID MGI:1913690
MGI Symbol Cdc26
EMBL AK012627 BC005775 BC114350
GenPept AAH05775 AAI14351 BAC25372
RNA Seq Atlas 66440

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca