Mus musculus Gene: Cdc26
Summary
InnateDB Gene IDBG-153053.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cdc26
Gene Name cell division cycle 26
Synonyms 2010012C09Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000066149
Encoded Proteins
cell division cycle 26
cell division cycle 26
cell division cycle 26
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176386:
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:62383654-62408642
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000084525 ENSMUSP00000081573
ENSMUST00000107459 ENSMUSP00000103083
ENSMUST00000134727 ENSMUSP00000120496
ENSMUST00000156854
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 18 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0007067 mitotic nuclear division
GO:0030071 regulation of mitotic metaphase/anaphase transition
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005680 anaphase-promoting complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Separation of Sister Chromatids pathway
Cellular responses to stress pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
M Phase pathway
Cell Cycle Checkpoints pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cellular Senescence pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Regulation of mitotic cell cycle pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Mitotic Metaphase and Anaphase pathway
Phosphorylation of the APC/C pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Adaptive Immune System pathway
Mitotic Spindle Checkpoint pathway
Mitotic Anaphase pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
Ubiquitin mediated proteolysis pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cellular responses to stress pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
APC/C-mediated degradation of cell cycle proteins pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Regulation of mitotic cell cycle pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Securin pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
Separation of Sister Chromatids pathway
Cell Cycle pathway
Adaptive Immune System pathway
Mitotic Spindle Checkpoint pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
M Phase pathway
Cellular Senescence pathway
Mitotic Anaphase pathway
Cell Cycle, Mitotic pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Class I MHC mediated antigen processing & presentation pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Phosphorylation of the APC/C pathway
Cell Cycle Checkpoints pathway
Mitotic Metaphase and Anaphase pathway
Regulation of APC/C activators between G1/S and early anaphase pathway
M Phase pathway
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Separation of Sister Chromatids pathway
Cellular responses to stress pathway
Mitotic Metaphase and Anaphase pathway
Mitotic Anaphase pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Cell Cycle, Mitotic pathway
Phosphorylation of the APC/C pathway
Cell Cycle pathway
Cellular Senescence pathway
Mitotic Spindle Checkpoint pathway
Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components pathway
APC/C:Cdc20 mediated degradation of Cyclin B pathway
Regulation of mitotic cell cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Inactivation of APC/C via direct inhibition of the APC/C complex pathway
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
Senescence-Associated Secretory Phenotype (SASP) pathway
Cell Cycle Checkpoints pathway
Autodegradation of Cdh1 by Cdh1:APC/C pathway
Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase pathway
APC/C:Cdc20 mediated degradation of Securin pathway
KEGG
Cell cycle pathway
Oocyte meiosis pathway
Ubiquitin mediated proteolysis pathway
Progesterone-mediated oocyte maturation pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q99JP4
TrEMBL
UniProt Splice Variant
Entrez Gene 66440
UniGene Mm.390677 Mm.398297 Mm.487307
RefSeq XM_006538173 NM_139291
OMIM
CCDS CCDS38774
HPRD
IMGT
MGI ID MGI:1913690
MGI Symbol Cdc26
EMBL AK012627 BC005775 BC114350
GenPept AAH05775 AAI14351 BAC25372
RNA Seq Atlas 66440