InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Aen

Summary

InnateDB Protein

IDBP-266711.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Aen

Protein Name

apoptosis enhancing nuclease

Synonyms

2700083B06Rik; Isg20l1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000103044

InnateDB Gene

IDBG-193491 (Aen)

Protein Structure

UniProt Annotation

Function

Exonuclease with activity against single- and double- stranded DNA and RNA. Mediates p53-induced apoptosis. When induced by p53 following DNA damage, digests double-stranded DNA to form single-stranded DNA and amplifies DNA damage signals, leading to enhancement of apoptosis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Nucleus, nucleolus {ECO:0000250}. Note=Localized predomintly in the nucleolus. Translocates from the nucleolus to the nucleoplasm upon apoptosis induction (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004527	exonuclease activity

Biological Process

GO:0010212	response to ionizing radiation
GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0090305	nucleic acid phosphodiester bond hydrolysis