Version 5.4
Mus musculus Protein: Jup
Summary
InnateDB Protein IDBP-266745.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Jup
Protein Name junction plakoglobin
Synonyms Ctnng; D930025P04Rik; PG;
Species Mus musculus
Ensembl Protein ENSMUSP00000103026
InnateDB Gene IDBG-211364 (Jup)
Protein Structure
UniProt Annotation
Function Common junctional plaque protein. The membrane- associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE- cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton. {ECO:0000269PubMed:19015309}.
Subcellular Localization Cell junction, adherens junction. Cell junction, desmosome. Cytoplasm, cytoskeleton. Membrane; Peripheral membrane protein. Note=Cytoplasmic in a soluble and membrane- associated form.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 69 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0005198 structural molecule activity
GO:0005488 binding
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0045294 alpha-catenin binding
GO:0045296 cadherin binding
Biological Process
GO:0000902 cell morphogenesis
GO:0002159 desmosome assembly
GO:0003136 negative regulation of heart induction by canonical Wnt receptor signaling pathway
GO:0003181 atrioventricular valve morphogenesis
GO:0003308 negative regulation of Wnt receptor signaling pathway involved in heart development
GO:0007016 cytoskeletal anchoring at plasma membrane
GO:0007155 cell adhesion
GO:0007369 gastrulation
GO:0007398 ectoderm development
GO:0007399 nervous system development
GO:0016331 morphogenesis of embryonic epithelium
GO:0016337 single organismal cell-cell adhesion
GO:0016477 cell migration
GO:0042127 regulation of cell proliferation
GO:0042307 positive regulation of protein import into nucleus
GO:0043588 skin development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048599 oocyte development
GO:0050982 detection of mechanical stimulus
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051291 protein heterooligomerization
GO:0071681 cellular response to indole-3-methanol
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086069 bundle of His cell to Purkinje myocyte communication
GO:0086091 regulation of heart rate by cardiac conduction
Cellular Component
GO:0005829 cytosol
GO:0005882 intermediate filament
GO:0005911 cell-cell junction
GO:0005913 cell-cell adherens junction
GO:0005915 zonula adherens
GO:0005916 fascia adherens
GO:0009898 cytoplasmic side of plasma membrane
GO:0015629 actin cytoskeleton
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0016327 apicolateral plasma membrane
GO:0016328 lateral plasma membrane
GO:0016342 catenin complex
GO:0030018 Z disc
GO:0030057 desmosome
GO:0030877 beta-catenin destruction complex
GO:0032993 protein-DNA complex
GO:0071665 gamma-catenin-TCF7L2 complex
Protein Structure and Domains
PDB ID MGI:96650
InterPro IPR000225 Armadillo
IPR013284 Beta-catenin
IPR016024 Armadillo-type fold
PFAM PF00514
PRINTS PR01869
PIRSF
SMART SM00185
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q02257
PhosphoSite PhosphoSite-Q02257
TrEMBL
UniProt Splice Variant
Entrez Gene 16480
UniGene Mm.486091
RefSeq
MGI ID
MGI Symbol Jup
OMIM
CCDS CCDS25420
HPRD
IMGT
EMBL AK170934 BC040757 BC094461 M90365
GenPept AAB02885 AAH40757 AAH94461 BAE42126

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca