InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Txnip

Summary

InnateDB Protein

IDBP-267395.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txnip

Protein Name

thioredoxin interacting protein

Synonyms

1200008J08Rik; AA682105; Hyplip1; Tbp-2; THIF; VDUP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000102710

InnateDB Gene

IDBG-175493 (Txnip)

Protein Structure

UniProt Annotation

Function

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1) (By similarity). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. {ECO:0000250, ECO:0000269PubMed:15723808, ECO:0000269PubMed:15930262}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10843682}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:10843682}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006606	protein import into nucleus
GO:0006979	response to oxidative stress
GO:0007049	cell cycle
GO:0009612	response to mechanical stimulus
GO:0009749	response to glucose
GO:0030216	keratinocyte differentiation
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043065	positive regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0051592	response to calcium ion
GO:0051782	negative regulation of cell division
GO:0071228	cellular response to tumor cell