InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Txnip

Summary

InnateDB Gene

IDBG-175493.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Txnip

Gene Name

thioredoxin interacting protein

Synonyms

1200008J08Rik; AA682105; Hyplip1; Tbp-2; THIF; VDUP1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000038393

Encoded Proteins

IDBP-175497

thioredoxin interacting protein

IDBP-267395

thioredoxin interacting protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22883233

Hyperactivated Ern1 (IRE1α) increases Txnip mRNA stability by reducing levels of a Txnip destabilizing microRNA, miR-17. In turn, elevated Txnip protein activates the Nlrp3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion. (Demonstrated in human)

InnateDB Annotation from Orthologs

Summary

PMID 22883233

[Homo sapiens] Hyperactivated ERN1 (IRE1α) increases TXNIP mRNA stability by reducing levels of a TXNIP destabilizing microRNA, miR-17. In turn, elevated TXNIP protein activates the NLRP3 inflammasome, causing procaspase-1 cleavage and interleukin 1β (IL-1β) secretion.

PMID 24217221

[Homo sapiens] Endoplasmic reticulum (ER) stress-mediated reactive oxygen species accumulation leads to activation of NLRP3 inflammasome through enhanced secretion of IL1B and binding of TXNIP.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog null:

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:96557957-96561883

Strand

Forward strand

Band

F2.1

Transcripts

ENSMUST00000049093	ENSMUSP00000041467
ENSMUST00000074519	ENSMUSP00000102710
ENSMUST00000151832
ENSMUST00000144639
ENSMUST00000128221

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006606	protein import into nucleus
GO:0006979	response to oxidative stress
GO:0007049	cell cycle
GO:0009612	response to mechanical stimulus
GO:0009749	response to glucose
GO:0030216	keratinocyte differentiation
GO:0032355	response to estradiol
GO:0032570	response to progesterone
GO:0042127	regulation of cell proliferation
GO:0042493	response to drug
GO:0042542	response to hydrogen peroxide
GO:0043065	positive regulation of apoptotic process
GO:0043086	negative regulation of catalytic activity
GO:0045087	innate immune response (InnateDB)
GO:0048008	platelet-derived growth factor receptor signaling pathway
GO:0051592	response to calcium ion
GO:0051782	negative regulation of cell division
GO:0071228	cellular response to tumor cell