InnateDB Protein
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IDBP-267609.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mapt
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Protein Name
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microtubule-associated protein tau
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Synonyms
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AI413597; AW045860; Mtapt; Tau;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000102605
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InnateDB Gene
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IDBG-213115 (Mapt)
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Protein Structure
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Function |
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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Subcellular Localization |
Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cell projection, axon. Note=Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.
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Disease Associations |
Note=May be involved in the pathogenesis of cytoplasmic inclusions (as Mallory bodies) in livers of mice chronically intoxicated with Griseofulvin or DDC (3,5-diethoxycarbonyl-2,4- dihydrocollidine), a model for human alcoholic hepatitis. Alteration of Tau (abnormal phosphorylation and cross-linking) could contribute to Mallory bodies formation and disturbance of microtubule function in alcoholic liver disease.
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Tissue Specificity |
Expressed in neurons and at a lower level in the liver and kidney. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated |
Total |
33
[view]
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Protein-Protein |
30
[view]
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Protein-DNA |
0
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Protein-RNA |
3
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
62 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:97180
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InterPro |
IPR001084
Microtubule associated protein, tubulin-binding repeat
IPR002955
Microtubule-associated protein Tau
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PFAM |
PF00418
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PRINTS |
PR01261
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P10637
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PhosphoSite |
PhosphoSite-P10637
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TrEMBL |
Q76M61
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UniProt Splice Variant |
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Entrez Gene |
17762
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UniGene |
Mm.417905
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RefSeq |
NP_034968
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MGI ID |
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MGI Symbol |
Mapt
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OMIM |
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CCDS |
CCDS25528
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HPRD |
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IMGT |
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EMBL |
AB061715
AB061716
AF483518
AF483519
AL593843
BC014748
CH466558
D30627
M18775
M18776
M93266
U12914
U12915
U12916
Z12133
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GenPept |
AAA40165
AAA40166
AAA58343
AAA58344
AAA58345
AAH14748
AAL90792
AAL90793
BAA18878
BAC20951
BAC20952
CAA78121
CAM14797
EDL34210
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