Mus musculus Gene: Mapt
Summary
InnateDB Gene IDBG-213115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mapt
Gene Name microtubule-associated protein tau
Synonyms AI413597; AW045860; Mtapt; Tau;
Species Mus musculus
Ensembl Gene ENSMUSG00000018411
Encoded Proteins
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
microtubule-associated protein tau
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000186868:
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer\'s disease, Pick\'s disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:104231390-104332090
Strand Forward strand
Band E1
Transcripts
ENSMUST00000100347 ENSMUSP00000097919
ENSMUST00000106993 ENSMUSP00000102606
ENSMUST00000106992 ENSMUSP00000102605
ENSMUST00000106989 ENSMUSP00000102602
ENSMUST00000106988 ENSMUSP00000102601
ENSMUST00000138384
ENSMUST00000145227 ENSMUSP00000114716
ENSMUST00000132977 ENSMUSP00000123260
ENSMUST00000146353
ENSMUST00000132245 ENSMUSP00000119145
ENSMUST00000144836
ENSMUST00000126820
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 33 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.
Experimentally validated
Total 33 [view]
Protein-Protein 30 [view]
Protein-DNA 0
Protein-RNA 3 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 62 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0017124 SH3 domain binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0034185 apolipoprotein binding
GO:0071813 lipoprotein particle binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0001764 neuron migration
GO:0007409 axonogenesis
GO:0007628 adult walking behavior
GO:0008088 axon cargo transport
GO:0010506 regulation of autophagy
GO:0031116 positive regulation of microtubule polymerization
GO:0032387 negative regulation of intracellular transport
GO:0045773 positive regulation of axon extension
GO:0047497 mitochondrion transport along microtubule
GO:0048675 axon extension
GO:0060632 regulation of microtubule-based movement
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005874 microtubule
GO:0005886 plasma membrane
GO:0005930 axoneme
GO:0015630 microtubule cytoskeleton
GO:0030424 axon
GO:0030426 growth cone
GO:0034399 nuclear periphery
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0045298 tubulin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Apoptosis pathway
Apoptotic cleavage of cellular proteins pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
Apoptotic execution phase pathway
KEGG
MAPK signaling pathway pathway
Alzheimer's disease pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
IL6 pathway
Leptin pathway
REACTOME
Apoptotic execution phase pathway
Apoptosis pathway
Apoptotic cleavage of cellular proteins pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
Apoptotic cleavage of cellular proteins pathway
Caspase-mediated cleavage of cytoskeletal proteins pathway
Apoptotic execution phase pathway
Apoptosis pathway
KEGG
MAPK signaling pathway pathway
Alzheimer's disease pathway
INOH
PID BIOCARTA
Deregulation of cdk5 in alzheimers disease [Biocarta view]
Bioactive peptide induced signaling pathway [Biocarta view]
PID NCI
LPA receptor mediated events
Reelin signaling pathway
Signaling mediated by p38-gamma and p38-delta
LKB1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.1287 Mm.417905
RefSeq NM_001038609 NM_001285455 NM_010838 XM_006532407
OMIM
CCDS CCDS25527 CCDS25528
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas